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Case Reports
. 1995 Feb;48(2):181-2.
doi: 10.1136/jcp.48.2.181.

Renal failure in a patient with chronic lymphocytic leukaemia treated with fludarabine

M P Macheta  1 , L A Parapia, D R Gouldesbrough
Affiliations
Case Reports

Renal failure in a patient with chronic lymphocytic leukaemia treated with fludarabine

M P Macheta et al. J Clin Pathol. 1995 Feb.

Abstract

The case history of a man with refractory chronic lymphocytic leukaemia who developed acute renal failure following treatment with fludarabine is presented. A renal biopsy specimen showed features of mesangiocapillary glomerulonephritis, a rare occurrence in chronic lymphocytic leukaemia. The rapid cytocidal action of fludarabine may result in the development of renal glomerular lesions when used to treat a well differentiated B cell malignancy.

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