Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Jun;69(6):3683-9.
doi: 10.1128/JVI.69.6.3683-3689.1995.

Cytopathogenicity of classical swine fever virus caused by defective interfering particles

G Meyers  1 , H J Thiel
Affiliations

Cytopathogenicity of classical swine fever virus caused by defective interfering particles

G Meyers et al. J Virol. 1995 Jun.

Abstract

For three independent cytopathogenic isolates of classical swine fever virus, defective RNAs were found in infected cells in addition to full-length viral genomes. These RNAs represent the genomes of typical defective interfering (DI) particles because of strict dependence on a complementing helper virus and interference with the replication of the helper virus. Analysis of the DI genomes revealed internal deletions of 4,764 nucleotides encompassing the complete structural protein-coding region of the virus and two flanking nonstructural genes. Plaque isolation and RNA transfection experiments showed that the DI particles are responsible for the cytopathic effect caused by these classical swine fever virus isolates.

PubMed Disclaimer

References

    1. Curr Top Microbiol Immunol. 1986;128:55-84 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2330-4 - PubMed
    1. J Am Vet Med Assoc. 1987 Jun 1;190(11):1449-58 - PubMed
    1. Virology. 1988 Jul;165(1):200-8 - PubMed
    1. J Virol. 1988 Aug;62(8):2823-7 - PubMed

Publication types

Associated data