[Effects of ulinastatin on renal function after subrenal aortic cross-clamping]

Abstract

Ten patients who had undergone temporary occlusion of the abdominal aorta below the origin of the renal arteries were studied to evaluate the effect of ulinastatin on the postoperative renal function after abdominal aortic cross-clamping. They were divided into two groups: ulinastatin group (ulinastatin 300,000 units.day-1 during intraoperative and postoperative three days, N = 5), control group (N = 5). In ulinastatin group, the increase of N-acetyl-beta-D-glucosaminidase on the third postoperative day was inhibited and renal function was well maintained. These results suggest that the administration of ulinastatin in perioperative day prevents postoperative renal dysfunction after abdominal aortic cross-clamping.