Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 May 20;345(8960):1277-8.
doi: 10.1016/s0140-6736(95)90928-1.

Predictive value of fetal serum beta 2-microglobulin for neonatal renal function

S M Berry  1 , B Lecolier, R S Smith, G Bercau, M P Dombrowski, K S Puder, K Kithier, L Bidat, M P Johnson, D B Cotton
Affiliations

Predictive value of fetal serum beta 2-microglobulin for neonatal renal function

S M Berry et al. Lancet. .

Abstract

When fetal urinary-tract malformations (UTM) are discovered, management is based on the prediction of postnatal renal function, currently made by fetal urinary biochemistry and sonography. Serum beta 2-microglobulin has been used postnatally to estimate renal function and does not cross the placenta. We investigated the relation between fetal serum beta 2-microglobulin and renal function by comparing 64 unaffected fetuses and 15 fetuses with UTM. A beta 2-microglobulin above a 5.6 mg/L cut-off gave cross-validated sensitivity of 80.0%, specificity of 98.6%, a positive predictive value of 88.9%, and a negative predictive value of 97.1% for our cohort study.

PubMed Disclaimer

Substances

LinkOut - more resources