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. 1995 May;45(5):947-50.
doi: 10.1212/wnl.45.5.947.

Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia

M A Pavol  1 , C A Meyers, J L Rexer, A D Valentine, P J Mattis, M Talpaz
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Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia

M A Pavol et al. Neurology. 1995 May.

Abstract

We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-alpha is highly suggestive of frontal-subcortical brain dysfunction.

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  • Interferon ALFA.
    Ikeda K, Kinoshitz M. Ikeda K, et al. Neurology. 1996 Jul;47(1):308-9. doi: 10.1212/wnl.47.1.308-a. Neurology. 1996. PMID: 8710113 No abstract available.

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