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. 1995 Jan-Feb;89(1):90-1.
doi: 10.1016/0035-9203(95)90672-x.

Chloroquine resistance of Plasmodium falciparum: a biological advantage?

W H Wernsdorfer  1 , B Landgraf, G Wiedermann, H Kollaritsch
Affiliations

Chloroquine resistance of Plasmodium falciparum: a biological advantage?

W H Wernsdorfer et al. Trans R Soc Trop Med Hyg. 1995 Jan-Feb.

Abstract

The response in vitro of Plasmodium falciparum to chloroquine, mefloquine and quinine was studied in a hyperendemic peri-urban area of Accra, Ghana, during the fourth quarter of 1991, yielding a total of 159 valid tests. Schizont maturation in drug-free controls and effective chloroquine concentrations were strongly correlated. This was not seen with mefloquine or quinine. Higher mean parasitaemia in untreated oligo-symptomatic carriers of overtly chloroquine-resistant P. falciparum than in carriers of more sensitive parasites was another indication of higher viability and biological advantage of chloroquine-resistant P. falciparum that may conceivably have clinical implications.

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