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Case Reports
. 1995 Mar 13;56(1):76-9.
doi: 10.1002/ajmg.1320560117.

Premature centromere division: a possible manifestation of chromosome instability

K Méhes  1 , E M Bühler
Affiliations
Case Reports

Premature centromere division: a possible manifestation of chromosome instability

K Méhes et al. Am J Med Genet. .

Abstract

Retrospective analysis of "routine" chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxia-teleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.

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