Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Mar;302(1):119-21.
doi: 10.1007/BF00586607.

Ethanol-induced alterations in histamine content and release in the rat hypothalamus

N Subramanian, P Mitznegg, C J Estler

Ethanol-induced alterations in histamine content and release in the rat hypothalamus

N Subramanian et al. Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar.

Abstract

In the rat hypothalamus, histamine content and histidine decarboxylas: activity are enhanced significantly after acute administration (80--160 mg/100g body weight) of ethanol. The effects are less pronounced after chronic treatment (15% v/v in drinking water for 4 weeks). Histamine methyltransferase is unaffected in either case. In hypothalamic slices preloaded with 3H-histamine and superfused with amine free solution the basal and K+-induced efflux of 3H-histamine are inhibited by alcohol. The inhibition of histamine release along with the increased levels of histamine may play an important role in the central effects of alcohol.

PubMed Disclaimer

References

    1. J Neurochem. 1972 May;19(5):1343-58 - PubMed
    1. Agents Actions. 1973 Oct;3(3):196 - PubMed
    1. Eur J Pharmacol. 1976 Jan;35(1):203-6 - PubMed
    1. Anat Rec. 1972 Oct;174(2):227-37 - PubMed
    1. Brain Res. 1976 Apr 23;106(2):333-48 - PubMed