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. 1994;76(10-11):968-80.
doi: 10.1016/0300-9084(94)90022-1.

The chromatin-associated protein H-NS

D W Ussery  1 , J C Hinton, B J Jordi, P E Granum, A Seirafi, R J Stephen, A E Tupper, G Berridge, J M Sidebotham, C F Higgins
Affiliations

The chromatin-associated protein H-NS

D W Ussery et al. Biochimie. 1994.

Abstract

H-NS is a major component of chromatin in enteric bacteria. H-NS plays a structural role in organising the chromosome, and influences DNA rearrangements as well as the expression of many genes. The biochemical and functional characteristics of H-NS are distinct from those of 'typical' DNA-binding proteins and much remains to be learned about the mechanism(s) by which H-NS acts. In this article we review our current understanding of the role of H-NS, and describe possible models by which H-NS might influence DNA structure and gene expression.

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