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Review
. 1995 Feb;5(1):84-90.
doi: 10.1016/s0959-437x(95)90058-6.

Biochemical properties and biological effects of p53

R Haffner  1 , M Oren
Affiliations
Review

Biochemical properties and biological effects of p53

R Haffner et al. Curr Opin Genet Dev. 1995 Feb.

Abstract

Over the past year, insights have been made into the biochemistry and biological effects of p53. The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the protein, important p53 target genes (such as WAF1) have been identified, and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.

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