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Comparative Study
. 1995 May;126(5 Pt 1):762-4.
doi: 10.1016/s0022-3476(95)70408-6.

Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva

T F Lanchoney  1 , R B Cohen, D M Rocke, M A Zasloff, F S Kaplan
Affiliations
Comparative Study

Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva

T F Lanchoney et al. J Pediatr. 1995 May.

Abstract

In patients who have fibrodysplasia ossificans progressiva, routine childhood diphtheria-tetanus-pertussis immunizations administered by intramuscular injection caused a significant risk of permanent heterotopic ossification at the site of injection (p < 10(-8)), whereas measles-mumps-rubella immunizations administered by subcutaneous injection posed no significant risk. Intramuscular injections should be avoided, if possible, once a diagnosis of fibrodysplasia ossificans progressiva has been established.

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