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Comparative Study
. 1995 May 9;92(10):4362-6.
doi: 10.1073/pnas.92.10.4362.

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1

M A Brown  1 , K A Jones, H Nicolai, M Bonjardim, D Black, R McFarlane, P de Jong, J P Quirk, H Lehrach, E Solomon
Affiliations
Comparative Study

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1

M A Brown et al. Proc Natl Acad Sci U S A. .

Abstract

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35.

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References

    1. Science. 1990 Dec 21;250(4988):1684-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 May 1;88(9):4005-9 - PubMed
    1. Eur J Biochem. 1992 Oct 1;209(1):459-66 - PubMed
    1. Am J Hum Genet. 1993 Apr;52(4):678-701 - PubMed
    1. Genomics. 1993 Sep;17(3):618-23 - PubMed

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