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. 1995 May 9;92(10):4562-6.
doi: 10.1073/pnas.92.10.4562.

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas

R K Singh  1 , M Gutman, C D Bucana, R Sanchez, N Llansa, I J Fidler
Affiliations

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas

R K Singh et al. Proc Natl Acad Sci U S A. .

Abstract

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Down-regulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (> 10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

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