Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976;293(1):105-8.
doi: 10.1007/BF00498878.

Lack of correlation between changes in cyclic nucleotides and subsequent induction of tyrosine hydroxylase in rat adrenal medulla

U Otten, H Thoenen

Lack of correlation between changes in cyclic nucleotides and subsequent induction of tyrosine hydroxylase in rat adrenal medulla

U Otten et al. Naunyn Schmiedebergs Arch Pharmacol. 1976.

Abstract

Pretreatment of rats with dexamethasone (2.5 mumol/kg, a dose which blocks the release of ACTH from the pituitary gland) abolished the reserpine mediated increase in cAMP and the increase in the cAMP/cGMP ratio in the adrenal medulla. In contrast, the reserpine-mediated induction of tyrosine hydroxylase (TH) remained unchanged. Hypophysectomy had a similar effect to dexamethasone treatment. Since changes in cAMP and changes in the cAMP/cGMP ratio are not indispensible prerequisities for the subsequent induction of TH, a causal relationship between the two phenomena seems to be excluded.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Science. 1973 Mar 2;179(4076):902-4 - PubMed
    1. Endocrinology. 1974 Jan;94(1):61-73 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1974;284(1):55-61 - PubMed
    1. J Pharmacol Exp Ther. 1975 Apr;193(1):95-104 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(2):157-70 - PubMed