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. 1995 Mar;68(3):946-8.
doi: 10.1016/S0006-3495(95)80270-5.

Activation of ryanodine receptors by flash photolysis of caged Ca2+

G D Lamb  1 , D G Stephenson
Affiliations

Activation of ryanodine receptors by flash photolysis of caged Ca2+

G D Lamb et al. Biophys J. 1995 Mar.

Abstract

Flash photolysis of DM-nitrophen generates an extremely large [Ca2+] transient ("Ca2+ spike") at the start of each Ca2+ "step." The Ca2+ spike greatly increases the speed of activation of the ryanodine receptor channel ("supercharging") and could be responsible for apparent channel adaptation.

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