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. 1995 Jun 3;345(8962):1408.
doi: 10.1016/s0140-6736(95)92600-3.

Impaired nocturnal secretion of melatonin in coronary heart disease

P Brugger  1 , W Marktl, M Herold
Affiliations

Impaired nocturnal secretion of melatonin in coronary heart disease

P Brugger et al. Lancet. .

Abstract

Patients with coronary heart disease have increased nocturnal urinary noradrenaline. Because melatonin suppresses sympathetic activity, we measured serum melatonin concentrations at night (0200 h) in 15 patients with coronary heart disease. Melatonin was significantly lower in the patients than in 10 healthy controls (median 7.8 [interquartile range 6.5-11.8] vs 36.2 [32.2-42.5] pg/mL, p < 0.0001). Thus, impaired nocturnal secretion of melatonin is associated with coronary heart disease.

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  • Melatonin secretion and coronary heart disease.
    Nagtegaal E, Smits M, Swart W, van der Meer G, Kerkhof G. Nagtegaal E, et al. Lancet. 1995 Nov 11;346(8985):1299. doi: 10.1016/s0140-6736(95)91901-5. Lancet. 1995. PMID: 7475742 No abstract available.

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