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Review
. 1993 Oct;4(5):577-82.
doi: 10.1016/0958-1669(93)90080-g.

Gene targeting in mammalian cells by homologous recombination

B Morrow  1 , R Kucherlapati
Affiliations
Review

Gene targeting in mammalian cells by homologous recombination

B Morrow et al. Curr Opin Biotechnol. 1993 Oct.

Abstract

Gene targeting by homologous recombination is a genetic tool that permits modification of cellular genes in a precise and predetermined fashion. The methodologies that are currently available permit gene targeting at high efficiency and fidelity. New developments promise large-scale modification of the mammalian genome using these techniques.

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