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. 1993 Nov;40(2-3):370-4.
doi: 10.1007/BF00170395.

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase

R B Lingham  1 , K C Silverman, G F Bills, C Cascales, M Sanchez, R G Jenkins, S E Gartner, I Martin, M T Diez, F Peláez, et al.
Affiliations

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase

R B Lingham et al. Appl Microbiol Biotechnol. 1993 Nov.

Abstract

Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.

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