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. 1994 Oct;58(10):1889-91.
doi: 10.1271/bbb.58.1889.

Regulated expression of an osteonectin variant in bovine aortic endothelial cells

H Jeon  1 , T Niimi, Y Taniguchi, K Miki, Y Kitagawa
Affiliations
Free article

Regulated expression of an osteonectin variant in bovine aortic endothelial cells

H Jeon et al. Biosci Biotechnol Biochem. 1994 Oct.
Free article

Abstract

Using a mouse SPARC (Secreted Protein, Acidic and Rich in Cysteine) cDNA clone as the probe, three clones were isolated from a cDNA library of bovine aortic endothelial cells (BAEC). Inserted sequences in them were identical with that of bovine bone osteonectin except for the deletion of the TGC codon encoding Cys-193. Northern blot analysis and metabolic radio-labeling of BAEC showed that gene expression and synthesis of the osteonectin variant is stimulated by transforming growth factor (TGF) beta, a basic fibroblast growth factor (FGF), or a naturally occurring splicing variant of hepatocyte growth factor (varHGF).

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