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. 1995 Apr;43(1):52-7.
doi: 10.1007/BF00170622.

The resistance of cellulases and xylanases to proteolytic inactivation

C M Fontes  1 , J Hall, B H Hirst, G P Hazlewood, H J Gilbert
Affiliations

The resistance of cellulases and xylanases to proteolytic inactivation

C M Fontes et al. Appl Microbiol Biotechnol. 1995 Apr.

Abstract

The sensitivity of a range of cellulases and xylanases to proteolytic inactivation was investigated. The xylanases, all the Clostridium thermocellum cellulases and cellulase E from Pseudomonas fluorescens subsp. cellulosa exhibited no decrease in catalytic activity during a 3-h incubation with proteinases of the small intestine. Under these conditions, the control Escherichia coli enzymes analysed had half-lives of 4.3-13.5 min. The addition of substrate significantly decreased the sensitivity of proteinase-labile enzymes to inactivation. The significance of these data in relation to the use of cellulases and xylanases for improving animal nutrition is discussed.

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