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Review
. 1995 Apr;20(4):156-60.
doi: 10.1016/s0968-0004(00)88993-8.

The mechanisms of DNA topoisomerases

J Roca  1
Affiliations
Review

The mechanisms of DNA topoisomerases

J Roca. Trends Biochem Sci. 1995 Apr.

Abstract

Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.

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