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. 1995 Mar 15;37(6):376-82.
doi: 10.1016/0006-3223(94)00132-M.

CRH challenge test in anxious depression

W H Meller  1 , R G Kathol, S D Samuelson, T L Gehris, B T Carroll, A F Pitts, P J Clayton
Affiliations

CRH challenge test in anxious depression

W H Meller et al. Biol Psychiatry. .

Abstract

Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.

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