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Comparative Study
. 1995 Jun;6(2):119-26.
doi: 10.1007/BF00695342.

Metabolism of halohydroquinones in Rhodococcus chlorophenolicus PCP-1

J S Uotila  1 , V H Kitunen, T Coote, T Saastamoinen, M Salkinoja-Salonen, J H Apajalahti
Affiliations
Comparative Study

Metabolism of halohydroquinones in Rhodococcus chlorophenolicus PCP-1

J S Uotila et al. Biodegradation. 1995 Jun.

Abstract

The actinomycete Rhodococcus chlorophenolicus PCP-1 metabolizes pentachlorophenol into ultimate inorganic end products via tetrachloro-p-hydroquinone. This intermediate was further dehalogenated in the cytoplasm requiring reductant in the cell free system. Tetrafluoro-p-hydroquinone and tetrabromo-p-hydroquinone were also dehalogenated. Chlorophenol analogs, thiol blocking agents and molecular oxygen inhibited the activity. The dehalogenating reactions led to 1,2,4-trihydroxybenzene, which was further metabolized into maleic acid.

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