Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Dec;1(12):877-90.
doi: 10.1038/nsb1294-877.

Solution structure of the tetrameric minimum transforming domain of p53

W Lee  1 , T S Harvey, Y Yin, P Yau, D Litchfield, C H Arrowsmith
Affiliations
Comparative Study

Solution structure of the tetrameric minimum transforming domain of p53

W Lee et al. Nat Struct Biol. 1994 Dec.

Erratum in

  • Nat Struct Biol 1995 Jan;2(1):81

Abstract

We report the solution structure of the minimum transforming domain (residues 303-366) of human p53 (p53tet) determined by multidimensional NMR spectroscopy. This domain contains a number of important functions associated with p53 activity including transformation, oligomerization, nuclear localization and a phosphorylation site for p34/cdc2 kinase. p53tet forms a symmetric dimer of dimers that is significantly different from a recent structure reported for a shorter construct of this domain. Phosphorylation of Ser 315 has only minor structural consequences, as this region of the protein is unstructured. Modelling based on the p53tet structure suggests possible modes of interaction between adjacent domains in full-length p53 as well as modes of interaction with DNA.

PubMed Disclaimer

Publication types

LinkOut - more resources