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. 1995 Feb;20(1):41-4.
doi: 10.1111/j.1365-2710.1995.tb00624.x.

Shelf-life determination of prostaglandin E1 injections

N H Shulman  1 , R K Fyfe
Affiliations

Shelf-life determination of prostaglandin E1 injections

N H Shulman et al. J Clin Pharm Ther. 1995 Feb.

Abstract

A rapid stability indicating assay for the determination of prostaglandin E1 (PGE1) in pharmaceuticals was developed using High Pressure Liquid Chromatography (HPLC). A solution of 20 micrograms/ml PGE1 in 4% alcohol and 0.9% saline has an activation energy of 18,683 cal/mol and the predicted shelf-lives were: at 4 degrees C t95 = 51.8 days and t90 = 106.5 days and at 25 degrees C t95 = 4.8 days and t90 = 9.8 days.

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