Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Nov;128(2):85-9.
doi: 10.1007/BF01103014.

Effect of amphotericin B on the lipids of five different strains of Cryptococcus neoformans

S P Franzot  1 , J S Hamdan
Affiliations
Comparative Study

Effect of amphotericin B on the lipids of five different strains of Cryptococcus neoformans

S P Franzot et al. Mycopathologia. 1994 Nov.

Abstract

Cells of five strains of Cryptococcus neoformans were obtained for partial analysis of lipid composition. Quantitative analysis of lipids and sterols were completed, as well as qualitative analysis of sterols by thin-layer chromatography and by the ultraviolet spectra. Such determinations were made on cells cultured in the absence and presence of amphotericin B at sub-MIC (minimal inhibitory concentration) levels. Marked alterations of the lipid and sterol contents were observed in the amphotericin B-treated cells. Moreover, ergosterol disappeared in these antibiotic-exposed cells. It is concluded that amphotericin B altered the lipid profiles, especially sterols of C. neoformans.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1992 Sep;36(9):1805-9 - PubMed
    1. Mycopathologia. 1988 May;102(2):97-105 - PubMed
    1. J Clin Microbiol. 1992 Nov;30(11):2881-6 - PubMed
    1. Mycopathologia. 1986 Apr;94(1):27-30 - PubMed
    1. Antimicrob Agents Chemother. 1974 Jul;6(1):102-13 - PubMed

Publication types

MeSH terms