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Comparative Study
. 1995 Jan-Mar;47(1-3):111-6.
doi: 10.1007/BF02790107.

Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation

H Hida  1 , C Coudray, J Calop, A Favier
Affiliations
Comparative Study

Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation

H Hida et al. Biol Trace Elem Res. 1995 Jan-Mar.

Abstract

Adriamycin (25 microM) stimulated NADPH-dependent microsomal lipid peroxidation about fourfold over control values. The tested antioxidants, zinc, superoxide dismutase, vitamin E, and desferrioxamine (Desferal) inhibited Adriamycin-enhanced lipid peroxidation to varying degrees. Others antioxidants, e.g., glutathione, catalase, and selenium, were found to have no effects. Our in vitro studies suggest that adriamycin effect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small amounts of iron.

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