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Clinical Trial
. 1976 Apr;39(4):350-6.
doi: 10.1136/jnnp.39.4.350.

Comparison of dantrolene sodium and diazepam in the treatment of spasticity

R T Schmidt, R H Lee, R Spehlmann
Clinical Trial

Comparison of dantrolene sodium and diazepam in the treatment of spasticity

R T Schmidt et al. J Neurol Neurosurg Psychiatry. 1976 Apr.

Abstract

The effects of dantrolene sodium and diazepam were compared in a double crossover study of 42 patients with spasticity due to stable multiple sclerosis. Both drugs reduced the findings of spasticity, clonus, and hyperreflexia, and the complaints of muscle stiffness and cramping. Each drug had different side effects which suggest indications and contraindications for its use in spastic patients.

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