Bradykinin-induced shifts in microhemodynamics, lymph production and flow in cat intestine; the effect of gut denervation

Abstract

In experiments on anaesthetized cats increased doses of bradykinin were administered intraarterially into an innervated part of the small intestine perfused in situ with constant inflow. It is concluded that the main factor accelerating transcapillary fluid efflux and lymph flow in this region with bradykinin is the rise in permeability of gut capillaries. This is confirmed by elevation in capillary filtration coefficient which takes place on the background of an increase in capillary hydrostatic pressure (when the intestine is naturally blood supplied), as decrease in the latter (when the preparation is perfused under constant inflow). The gut denervation decreasing regional vascular tone modifies bradykinin-induced lymph flow and shifts of hemodynamics in the small intestine. In denervated small intestine when compared with innervated ones bradykinin causes less expressed increase in lymph production and capillary hydrostatic pressure, but more marked elevation in capillary filtration coefficient.