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. 1995 Apr;39(4):1007-9.
doi: 10.1128/AAC.39.4.1007.

Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation

E R Dabbs  1 , K Yazawa, Y Mikami, M Miyaji, N Morisaki, S Iwasaki, K Furihata
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Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation

E R Dabbs et al. Antimicrob Agents Chemother. 1995 Apr.

Abstract

Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV and 23-[O-(alpha-D-ribofuranosyl)]rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivation.

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References

    1. Antimicrob Agents Chemother. 1989 Dec;33(12):2089-91 - PubMed
    1. J Med Chem. 1990 May;33(5):1470-6 - PubMed
    1. FEMS Microbiol Lett. 1991 Apr 15;63(2-3):247-50 - PubMed
    1. Diagn Microbiol Infect Dis. 1994 Apr;18(4):219-27 - PubMed
    1. Antimicrob Agents Chemother. 1994 Sep;38(9):2197-9 - PubMed

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