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. 1976 Jun;73(6):1877-81.
doi: 10.1073/pnas.73.6.1877.

Protein-protein interaction in transport: periplasmic histidine-binding protein J interacts with P protein

G F Ames, E N Spurich

Protein-protein interaction in transport: periplasmic histidine-binding protein J interacts with P protein

G F Ames et al. Proc Natl Acad Sci U S A. 1976 Jun.

Abstract

A component of the high-affinity histidine transport system in Salmonella typhimurium, the periplasmic histidine-binding protein J, interacts with another transport component, the P protein. A mutant J protein, with a defective interaction site but intact histidine-binding site, can function in histidine transport if an appropriate compensating mutation is introduced in the P protein. The interaction between the J and P proteins is an obligatory step in transport. The significance of this interaction and of the involvement of the P protein in multiple transport functions is discussed.

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References

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