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. 1995;70(3-4):255-7.
doi: 10.1159/000134046.

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-->q13

C E Carow  1 , E Kim, A L Hawkins, H D Webb, C A Griffin, E W Jabs, C I Civin, D Small
Affiliations

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-->q13

C E Carow et al. Cytogenet Cell Genet. 1995.

Abstract

We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12-->q13.

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