GM1 antibody in Guillain-Barre syndrome after Campylobacter jejuni infection

Abstract

Fecal culture of Campylobacter jejuni was prepared by the method of Skirrow, and serum class specific antibodies (IgG, IgM and IgA) to Campylobacter jejuni and serum class specific antibodies (IgG IgM) to GM1 were prepared with solid phase enzyme linked immunasorbent assay in 16 cases of Guillain-Barre syndrome (GBS), 32 controls with other neurological diseases (disease controls) and 90 normal controls. The results showed that the incidence of Campylobacter jejuni infection, especially recent infections, in the group with Guillain-Barre syndrome was much higher than that in the two control groups, and that the positive rate of GM1 antibody was also much higher in the GBS group than in the two control groups. The results suggest that Campylobacter jejuni infection may be one of the important precipitating factors of Guillain-Barre syndrome and play an important role in the epidemiological pattern of Guillain-Barre syndrome in China. It damages the myelin of peripheral nerves through induction of GM1 antibody production.