Disturbances of cortical development

Abstract

The development processes coinciding in formation of cerebral cortex were presented. On this background may arise the cortical developmental abnormalities. The review of principal cortical malformations include the 1) agyria-pachygyria - lissencephaly type I, 2) polymicrogyria, 3) disorganized cortical structure - lissencephaly type II, 4) minor cortical developmental anomalies and 5) other cortical dysplasia syndromes. It will help to reconstruct the pathomechanism of cortical abnormal development from early occurring primary errors to late changes in which coincide necrotic lesions. The presented material illustrate the role of time of occurrence and intensity of damage in final result of pathologic developmental processes.