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Comparative Study
. 1995 Mar;4(3):534-7.
doi: 10.1002/pro.5560040319.

Structural features of the uniporter/symporter/antiporter superfamily

V C Goswitz  1 , R J Brooker
Affiliations
Comparative Study

Structural features of the uniporter/symporter/antiporter superfamily

V C Goswitz et al. Protein Sci. 1995 Mar.

Abstract

The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three-dimensional arrangement of the transmembrane domains.

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