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. 1995 Mar;12(1):45-51.

Hypothalamic hamartoma: anatomic, immunohistochemical and ultrastructural features

H K Inoue  1 , H Kanazawa, H Kohga, A Zama, N Ono, M Nakamura, C Ohye
Affiliations
  • PMID: 7795729

Hypothalamic hamartoma: anatomic, immunohistochemical and ultrastructural features

H K Inoue et al. Noshuyo Byori. 1995 Mar.

Abstract

Four patients with hypothalamic hamartoma were examined by CT and/or MR imaging, immunohistochemistry and electron microscopy. The hamartomas arose from the hypothalamus and extended inferiorly. LH-RH neurons were detected in three cases by immunohistochemistry. Electron microscopy revealed large myelinated axons, axon terminals containing dense-core vesicles and axon terminals with clear vesicles forming asymmetrical synapses. The development of hypothalamic hamartoma and its functional manifestations (precocious puberty and laugh attacks) are discussed in reference to the migration of LH-RH neurons from the olfactory placode.

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