Eosinophil adhesion in allergic inflammation

Abstract

Eosinophil adhesion has been studied in some detail in recent years, and a number of interesting observations have emerged. As with other aspects of eosinophil biology, there appears to be a greater similarity with basophils than with neutrophils in their pattern of adhesion interactions. A number of important differences with respect to neutrophils have emerged, which could be exploited for the treatment of eosinophil-mediated disease, including the observations that eosinophil adhesion can be modulated by selective cytokines such as IL-5 and that eosinophils, unlike neutrophils, express VLA-4 and alpha 4/beta 7. There is also tantalizing evidence emerging that eosinophils interact differentially with the selectins, with differing degrees of affinity of binding and possibly different counterreceptors. The extent to which these observations will be useful in treating allergic disease remains to be seen.