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. 1994 Sep;57(9):1316-9.
doi: 10.1021/np50111a026.

Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors

T Schmeller  1 , M Sauerwein, F Sporer, M Wink, W E Müller
Affiliations

Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors

T Schmeller et al. J Nat Prod. 1994 Sep.

Abstract

Fourteen quinolizidine alkaloids, isolated from Lupinus albus, L. mutabilis, and Anagyris foetida, were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. Of the compounds tested, the alpha-pyridones, N-methylcytisine and cytisine, showed the highest affinities at the nicotinic receptor, while several quinolizidine alkaloid types were especially active at the muscarinic receptor.

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