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Clinical Trial
. 1995 Jan;53(1):2-7; discussion 7-8.
doi: 10.1016/0278-2391(95)90486-7.

Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars

S Schultze-Mosgau  1 , R Schmelzeisen, J C Frölich, H Schmele
Affiliations
Clinical Trial

Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars

S Schultze-Mosgau et al. J Oral Maxillofac Surg. 1995 Jan.

Abstract

Purpose: To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling.

Methods: The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study.

Results: After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% (P < .001) compared with the placebo group; measurement with a tape measure showed a 58% (P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo.

Conclusion: The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action.

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