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Clinical Trial
. 1995 Jan;53(1):24-6; discussion 26-7.
doi: 10.1016/0278-2391(95)90493-x.

Inhalation sedation with sevoflurane: a comparative study with nitrous oxide

N Haraguchi  1 , H Furusawa, R Takezaki, K Oi
Affiliations
Clinical Trial

Inhalation sedation with sevoflurane: a comparative study with nitrous oxide

N Haraguchi et al. J Oral Maxillofac Surg. 1995 Jan.

Abstract

Purpose: To evaluate the possibility of using sevoflurane for inhalation sedation.

Patients and methods: Thirty-five volunteers were divided randomly into two groups: sevoflurane group (n = 20) and nitrous oxide (N2O) group (n = 15). At the beginning of the sedation they all inhaled 100% O2, then a 0.1 minimum alveolar concentration (MAC) of sevoflurane or 10% N2O with oxygen, a 0.2 MAC of sevoflurane or 20% N2O with oxygen, and 0.3 MAC of sevoflurane or 30% N2O with oxygen for 10 minutes each.

Results: The respiratory and cardiovascular functions were stable during inhalation of the gas mixtures. There were five negative comments about breathing N2O, but none about breathing sevoflurane.

Conclusion: All subjects in the sevoflurane group stated they would be willing to submit to the same inhalation procedure again.

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