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Clinical Trial
. 1995 Jan 7;345(8941):29-30.
doi: 10.1016/s0140-6736(95)91156-1.

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

A Howell  1 , D DeFriend, J Robertson, R Blamey, P Walton
Affiliations
Clinical Trial

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

A Howell et al. Lancet. .

Abstract

We treated 19 patients with advanced breast cancer resistant to tamoxifen with a new specific antioestrogen (ICI 182780) which, in animal studies, has no agonist activity. 13 (69%) patients responded (7 had partial responses and 6 showed no change) to monthly intramuscular injections of ICI 182780 after progression on tamoxifen, for a median duration of 18 months with minimum side effects. Preliminary evidence suggests that the agent is without effects on the liver or the hypothalamic-pituitary axis. ICI 182780 appears to be a promising new agent for treatment of advanced and early breast cancer.

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