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. 1994 Oct;88(2):392-4.
doi: 10.1111/j.1365-2141.1994.tb05036.x.

Hepatitis C virus infection in patients with non-Hodgkin's lymphoma

C Ferri  1 , F Caracciolo, A L Zignego, L La Civita, M Monti, G Longombardo, F Lombardini, F Greco, E Capochiani, A Mazzoni, et al.
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Hepatitis C virus infection in patients with non-Hodgkin's lymphoma

C Ferri et al. Br J Haematol. 1994 Oct.

Abstract

Hepatitis C virus (HCV), which is both a hepatotropic and a lymphotropic virus, has been proposed as a possible causative agent of mixed cryoglobulinaemia. This 'benign' lymphoproliferative disorder can switch over to a malignant B-cell non-Hodgkin's lymphoma (NHL). Therefore HCV infection has been investigated in a series of 50 unselected Italian patients with B-cell NHL. Antibodies against HCV were found in 30% of NHL and HCV viraemia in 32% of cases. HCV-related markers were detected in 34% (17/50) of our NHL patients; this prevalence is particularly significant when compared with HCV seropositivity in Hodgkin's lymphoma (3%) and healthy controls (1.3%).

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