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. 1995 Jan;63(1):71-6.
doi: 10.1016/s0015-0282(16)57299-9.

In vitro fertilization and oocyte donation in women 45 years of age and older

Y Yaron  1 , A Amit, S M Brenner, M R Peyser, M P David, J B Lessing
Affiliations
Free article

In vitro fertilization and oocyte donation in women 45 years of age and older

Y Yaron et al. Fertil Steril. 1995 Jan.
Free article

Abstract

Objective: To assess the reproductive potential in women > or = 45 years of age.

Design: Retrospective analysis.

Setting: In vitro fertilization-embryo transfer unit, standard IVF and oocyte donation programs.

Patients: One hundred twenty-seven patients > or = 45 years old who applied for treatment of infertility.

Intervention: Thirty-one patients underwent 52 treatment cycles in standard IVF. Ninety-six patients underwent 220 oocyte donation cycles.

Results: Of the 52 standard IVF cycles, oocytes were retrieved successfully in only 32. Of these, fertilization and ET were performed in 21 cycles. None of these treatment cycles resulted in a clinical pregnancy. Of the 220 oocyte donation cycles, fertilization and ET were accomplished in 189 cycles. These resulted in 33 (17.5% per transfer) clinical pregnancies.

Conclusions: These results suggest that oocyte donation may extend the reproductive potential in women > or = 45 years old when little hope is offered by standard IVF.

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