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Comparative Study
. 1994 Jul 15;22(2):381-7.
doi: 10.1006/geno.1994.1399.

Genetic analysis of colon cancer susceptibility in mice

R F Jacoby  1 , C Hohman, D J Marshall, T J Frick, S Schlack, M Broda, J Smutko, R W Elliott
Affiliations
Comparative Study

Genetic analysis of colon cancer susceptibility in mice

R F Jacoby et al. Genomics. .

Abstract

Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q.

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