Review
doi: 10.1083/jcb.127.6.1783.
Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction
Affiliations
- PMID: 7806559
- PMCID: PMC2120304
- DOI: 10.1083/jcb.127.6.1783
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Review
Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction
J Cell Biol.
1994 Dec.
Abstract
Epithelia and mesenchyme interact during various physiologic and pathologic processes. Scatter factor is a mesenchyme-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. Recent studies suggest that scatter factor and its receptor (c-met) mediate mesenchyme/epithelia signalling and even interconversion. In this mini-review, we will discuss how scatter factor and c-met may mediate interactions between mesenchyme and epithelia during embryogenesis, organ repair, and neoplasia.
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