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. 1994 Dec 20;91(26):12745-9.
doi: 10.1073/pnas.91.26.12745.

Pax-3 contains domains for transcription activation and transcription inhibition

G Chalepakis  1 , F S Jones, G M Edelman, P Gruss
Affiliations

Pax-3 contains domains for transcription activation and transcription inhibition

G Chalepakis et al. Proc Natl Acad Sci U S A. .

Abstract

Pax-3 is a member of the Pax family of transcription factors involved in transcriptional control events during embryonic development. Here we report a functional dissection of the Pax-3 protein and describe the protein domains which are responsible for different activities. A transcription inhibition activity is located in the first 90 N-terminal amino acids and includes part of the paired domain. Furthermore, the C terminus of Pax-3 is able to confer transcriptional activation of basal promoters. Pax-3 can utilize both transcription modulating functions and activates transcription over a narrow range of protein concentration in the presence of promoter elements containing functional binding sites.

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References

    1. Annu Rev Cell Biol. 1986;2:81-116 - PubMed
    1. Genomics. 1991 May;10(1):89-93 - PubMed
    1. Cell. 1991 Nov 15;67(4):767-74 - PubMed
    1. Nature. 1992 Feb 13;355(6361):635-6 - PubMed
    1. Nature. 1992 Feb 13;355(6361):637-8 - PubMed

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