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Comparative Study
. 1994 Dec 20;91(26):12952-6.
doi: 10.1073/pnas.91.26.12952.

A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis

O I Shamraj  1 , J B Lingrel
Affiliations
Comparative Study

A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis

O I Shamraj et al. Proc Natl Acad Sci U S A. .

Abstract

The Na+,K(+)-ATPase alpha subunit has three known isoforms, alpha 1, alpha 2 and alpha 3, each encoded by a separate gene. This study was undertaken to determine the functional status of a fourth human alpha-like gene, ATP1AL2. Partial genomic sequence analysis revealed regions exhibiting sequence similarity with exons 3-6 of the Na+,K(+)-ATPase alpha isoform genes. ATP1AL2 cDNAs spanning the coding sequence of a novel P-type ATPase alpha subunit were isolated from a rat testis library. The predicted polypeptide is 1028 amino acids long and exhibits 76-78% identity with the rat Na+,K(+)-ATPase alpha 1, alpha 2 and alpha 3 isoforms, indicating that ATP1AL2 may encode a fourth Na+,K(+)-ATPase alpha isoform. A 3.9-kb mRNA is expressed abundantly in human and rat testis.

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