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. 1994 Dec 20;91(26):12976-9.
doi: 10.1073/pnas.91.26.12976.

Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

V S Pande  1 , A Y Grosberg, T Tanaka
Affiliations

Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule

V S Pande et al. Proc Natl Acad Sci U S A. .

Abstract

We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an "active site" capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

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References

    1. Nature. 1992 Mar 12;356(6365):168-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12972-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7195-9 - PubMed

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