Review
Retinoblastoma
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- PMID: 7809503
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Review
Retinoblastoma
Semin Diagn Pathol.
1994 May.
Abstract
Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.
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