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Review
. 1994 May;11(2):104-6.

Retinoblastoma

G T Lueder  1 , M E Smith
Affiliations
  • PMID: 7809503
Review

Retinoblastoma

G T Lueder et al. Semin Diagn Pathol. 1994 May.

Abstract

Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.

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